I will try to explain the difference between the surgeries here:
A direct donation is from a friend or family member who is willing to donate a kidney to their loved one while still alive. There are two main criteria. The first is that you should have the same blood type. The second is a genetic match. The closer genetic match the more chance of a donated kidney lasting a longer period of time.
A non blood match donation can be made if the recipients blood antigens can be suppressed enough to allow the kidney to live. There are two things done. One is a drug that stops any proteins that the kidney might not like from attacking it and causing an immediate collapse. This is given one month before the operation and is a one time shot. The second part is a week of blood cleansing using a machine like a hemodialysis unit that removes the antigen that will hurt the new kidney. The blood is cleansed every day for a week before the operation. On the day of the operation the blood is tested an hour before the surgery and if the antigens are below a specified level the surgery will go ahead. If not the blood will once again be cleaned for a day and they will try again the next day. As you might have guessed this can mean one or more days of being prepped for surgery and then waiting for the next day for the antigens to come down.
The dangers of this surgery are that the kidney could fail in the first two weeks if everything doesn't go right, however after the danger period the kidney has the same prospects as a blood match kidney transplant. The advantage for Glory and I is two fold. First, we are a very close genetic match which would be hard to find in a non family donation. Second, the chance of a paired donation in the first year is about 15%. We could wait a year and hope for a blood match paired donation but the odds are very low and after a year we would still need to go through the above mentioned process.
A paired donation is one where you have two or more donors who are willing to donate a kidney to a loved one but don't have a blood match. If we take four people, two donors and two recipients, If donor one is an A blood type and their recipient is an O blood type as Glory and I are, the second donor would have to be an O blood type and their recipient would have to be an A blood type. There can be more than two donors/recipient combinations as well were each donor would match a recipient in the group so all would receive kidneys. The good part is that there is no blood match problem so no extra step. The bad part is that the genetic match may not be as strong requiring more anti rejection drugs and the above mentioned 15% chance of finding a match.
With the information given above, and the fact that the developer of the non blood transplant is the surgeon involved in the transplant at Guys where our surgery will be done has help Glory and I make up our decision to go to the non-blood match transplant. We have however stayed on the paired list as there is one draw to be done very soon to try and get a match. If this happened we would go ahead with a matched pair transplant.
I hope this might help those who have wanted more explanation of the different processes.
Hope this finds